François Schelcher

François Schelcher

Short Bio:

Address: Pathologie des ruminants, Ecole Nationale Vétérinaire, 23 chemin des Capelles, BP 87614, F – 31076 Toulouse cedex 03
Email address: f.schelcher@envt.fr
Date of birth: 1958, January 29th
Nationality: French
Education: veterinary medicine (ENV Toulouse) 1978 - 1982

Degrees:
-DVM (Toulouse 1984),
-Master (Diplôme d’Etudes Approfondies), Agricultural Economy (Toulouse University I 1984),
-Agrégation (French Veterinary Schools) (Paris, 1989),
-Master, Virology, Institut Pasteur de Paris (Paris, 1994),
-PhD “Immunophenotyping lymphoid cells of bovine bronchoalveolar lavage in BRSV infections” (Institut National Polytechnique, Toulouse, 1997)
- diplomate de facto of European College of Bovine Health Management (ECBHM) (2007)

Position

1. professor of ruminant medicine (since 1994)
2. head of Research Unit 1225 (INRA – ENVT) “Host - Pathogen Interactions” (since 2005)

Professional activities
Professional activities include

1. bovine internal medicine and surgery (Ruminant Clinics ENVT )
2. bovine and ovine population medicine, dedicated to diagnosis and control of herd diseases (nutritional and metabolic diseases, lameness, respiratory diseases, neonatal diarrhoea, abortion, infectious diseases -paratuberculosis, BVD infection…-).
3. research in different topics specifically related to ruminant health (respiratory diseases, prion diseases).

Publications
-original scientific articles in international peer reviewed journals (fields of virology ; microbiology ; infectious diseases ; veterinary sciences ; agriculture, dairy and animal sciences ) (annex 1)
-educational or review articles in veterinary journals

Annex 1 : List of original scientific articles in international peer reviewed journals

1. Tabouret G, Lacroux C, Lugan S, Costes P, Corbière F, Weisbecker JL, Schelcher F, Andréoletti O. Relevance of oral experimental challenge with classical scrapie in sheep. J Gen Virol. 2010 Aug;91(Pt 8):2139-44.
2. Laloy E, Petit E, Boulouis HJ, Lacroux C, Corbiere F, Schelcher F, Bonnet S, Maillard R. First detection of Anaplasma phagocytophilum-like DNA in the French izard Rupricapra pyrenaica. Clin Microbiol Infect. 2009 Dec;15 Suppl 2:26-7
3. Barillet F, Mariat D, Amigues Y, Faugeras R, Caillat H, Moazami-Goudarzi K, Rupp R, Babilliot JM, Lacroux C, Lugan S, Schelcher F, Chartier C, Corbière F, Andréoletti O, Perrin-Chauvineau C. Identification of seven haplotypes of the caprine PrP gene at codons 127, 142, 154, 211, 222 and 240 in French Alpine and Saanen breeds and their association with classical scrapie. J Gen Virol. 2009 Mar;90(Pt 3):769-76.
4. Lacroux C, Simon S, Benestad SL, Maillet S, Mathey J, Lugan S, Corbière F, Cassard H, Costes P, Bergonier D, Weisbecker JL, Moldal T, Simmons H, Lantier F, Feraudet-Tarisse C, Morel N, Schelcher F, Grassi J, Andréoletti O. Prions in milk from ewes incubating natural scrapie. PLoS Pathog. 2008 Dec;4(12):e1000238.
5. Desquesnes M, Bossard G, Patrel D, Herder S, Patout O, Lepetitcolin E, Thevenon S, Berthier D, Pavlovic D, Brugidou R, Jacquiet P, Schelcher F, Faye B, Touratier L, Cuny G. First outbreak of Trypanosoma evansi in camels in metropolitan France. Vet Rec. 2008 Jun 7;162(23):750-2.
6. Moreno CR, Cosseddu GM, Schibler L, Roig A, Moazami-Goudarzi K, Andreoletti O, Eychenne F, Lajous D, Schelcher F, Cribiu EP, Laurent P, Vaiman D, Elsen JM. Identification of new quantitative trait Loci (other than the PRNP gene) modulating the scrapie incubation period in sheep. Genetics. 2008 May;179(1):723-6.
7. Uro-Coste E, Cassard H, Simon S, Lugan S, Bilheude JM, Perret-Liaudet A, Ironside JW, Haik S, Basset-Leobon C, Lacroux C, Peoch' K, Streichenberger N, Langeveld J, Head MW, Grassi J, Hauw JJ, Schelcher F, Delisle MB, Andréoletti O. Beyond PrP9res) type 1/type 2 dichotomy in Creutzfeldt-Jakob disease. PLoS Pathog. 2008 Mar 14;4(3):e1000029.
8. Duchesne A, Manciaux L, Gautier M, Floriot S, Grohs C, Fritz S, Druet T, Schelcher F, Ducos A, Eggen A. A Generalized Caprine-like Hypoplasia Syndrome is localized within a 6-cM interval on bovine chromosome 13 in the Montbéliarde breed. Anim Genet. 2008 Apr;39(2):112-20.
9. Maillard R, Petit E, Chomel B, Lacroux C, Schelcher F, Vayssier-Taussat M, Haddad N, Boulouis HJ. Endocarditis in cattle caused by Bartonella bovis. Emerg Infect Dis. 2007 Sep;13(9):1383-5.
10. Meyer G, Deplanche M, Schelcher F. Human and bovine respiratory syncytial virus vaccine research and development. Comp Immunol Microbiol Infect Dis. 2008 Mar;31(2-3):191-225.
11. Deplanche M, Lemaire M, Mirandette C, Bonnet M, Schelcher F, Meyer G. In vivo evidence for quasispecies distributions in the bovine respiratory syncytial virus genome. J Gen Virol. 2007 Apr;88(Pt 4):1260-5.
12. Lacroux C, Corbière F, Tabouret G, Lugan S, Costes P, Mathey J, Delmas JM, Weisbecker JL, Foucras G, Cassard H, Elsen JM, Schelcher F, Andréoletti O. Dynamics and genetics of PrPSc placental accumulation in sheep. J Gen Virol. 2007 Mar;88(Pt 3):1056-61.
13. Corbière F, Barillet F, Andréoletti O, Fidelle F, Laphitz-Bordet N, Schelcher F, Joly P. Advanced survival models for risk-factor analysis in scrapie. J Gen Virol. 2007 Feb;88(Pt 2):696-705.
14. Andréoletti O, Morel N, Lacroux C, Rouillon V, Barc C, Tabouret G, Sarradin P, Berthon P, Bernardet P, Mathey J, Lugan S, Costes P, Corbière F, Espinosa JC, Torres JM, Grassi J, Schelcher F, Lantier F. Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep. J Gen Virol. 2006 Apr;87(Pt 4):1043-6.
15. Constable PD, Stämpfli HR, Navetat H, Berchtold J, Schelcher F. Use of a quantitative strong ion approach to determine the mechanism for acid-base abnormalities in sick calves with or without diarrhea. J Vet Intern Med. 2005 Jul-Aug;19(4):581-9.
16. Andréoletti O, Simon S, Lacroux C, Morel N, Tabouret G, Chabert A, Lugan S, Corbière F, Ferré P, Foucras G, Laude H, Eychenne F, Grassi J, Schelcher F. PrPSc accumulation in myocytes from sheep incubating natural scrapie. Nat Med. 2004 Jun;10(6):591-3.
17. Andreoletti O, Levavasseur E, Uro-Coste E, Tabouret G, Sarradin P, Delisle MB, Berthon P, Salvayre R, Schelcher F, Negre-Salvayre A. Astrocytes accumulate 4-hydroxynonenal adducts in murine scrapie and human Creutzfeldt-Jakob disease. Neurobiol Dis. 2002 Dec;11(3):386-93.
18. Andréoletti O, Berthon P, Levavasseur E, Marc D, Lantier F, Monks E, Elsen JM, Schelcher F. Phenotyping of protein-prion (PrPsc)-accumulating cells in lymphoid and neural tissues of naturally scrapie-affected sheep by double-labeling immunohistochemistry. J Histochem Cytochem. 2002 Oct;50(10):1357-70.
19. Andréoletti O, Lacroux C, Chabert A, Monnereau L, Tabouret G, Lantier F, Berthon P, Eychenne F, Lafond-Benestad S, Elsen JM, Schelcher F. PrP(Sc) accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission. J Gen Virol. 2002 Oct;83(Pt 10):2607-16.
20. Enjalbert F, Lebreton P, Salat O, Meschy F, Schelcher F. Effects of copper supplementation on the copper status of peripartum beef cows and their calves. Vet Rec. 2002 Jul 13;151(2):50-3.
21. Picard-Hagen N, Gayrard V, Laroute V, Grandjean C, Andreoletti O, Elsen JM, Schelcher F, Toutain PL. Discriminant value of blood and urinary corticoids for the diagnosis of scrapie in live sheep. Vet Rec. 2002 Jun 1;150(22):680-4.
22. Valarcher JF, Bourhy H, Lavenu A, Bourges-Abella N, Roth M, Andreoletti O, Ave P, Schelcher F. Persistent infection of B lymphocytes by bovine respiratory syncytial virus. Virology. 2001 Dec 5;291(1):55-67.
23. Poumarat F, Le Grand D, Philippe S, Calavas D, Schelcher F, Cabanié P, Tessier P, Navetat H. Efficacy of spectinomycin against Mycoplasma bovis induced pneumonia in conventionally reared calves. Vet Microbiol. 2001 May 3;80(1):23-35.
24. Andréoletti O, Berthon P, Marc D, Sarradin P, Grosclaude J, van Keulen L, Schelcher F, Elsen JM, Lantier F. Early accumulation of PrP(Sc) in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie. J Gen Virol. 2000 Dec;81(Pt 12):3115-26.
25. Valarcher JF, Schelcher F, Bourhy H. Evolution of bovine respiratory syncytial virus. J Virol. 2000 Nov;74(22):10714-28.
26. Gayrard V, Picard-Hagen N, Grino M, Sauze N, Grandjean C, Galea J, Andreoletti O, Schelcher F, Toutain PL. Major hypercorticism is an endocrine feature of ewes with naturally occurring scrapie. Endocrinology. 2000 Mar;141(3):988-94.
27. Bendali F, Sanaa M, Bichet H, Schelcher F. Risk factors associated with diarrhoea in newborn calves. Vet Res. 1999 Sep-Oct;30(5):509-22.
28. Vende P, Karoum R, Manet G, Rizet C, Schelcher F, Cohen J, Navetat H. Molecular epidemiology or bovine rotaviruses from the Charolais area. Vet Res. 1999 Sep-Oct;30(5):451-6.
29. Valarcher JF, Bourhy H, Gelfi J, Schelcher F. Evaluation of a nested reverse transcription-PCR assay based on the nucleoprotein gene for diagnosis of spontaneous and experimental bovine respiratory syncytial virus infections. J Clin Microbiol. 1999 Jun;37(6):1858-62.
30. Elsen JM, Amigues Y, Schelcher F, Ducrocq V, Andreoletti O, Eychenne F, Khang JV, Poivey JP, Lantier F, Laplanche JL. Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov. Arch Virol. 1999;144(3):431-45.
31. Schelcher F, Picard-Hagen N, Laroute V, Gayrard V, Popot MA, Andreoletti O, Toutain PL. Corticoid concentrations are increased in the plasma and urine of ewes with naturally occurring scrapie. Endocrinology. 1999 May;140(5):2422-5.
32. Bendali F, Bichet H, Schelcher F, Sanaa M. Pattern of diarrhoea in newborn beef calves in south-west France. Vet Res. 1999 Jan-Feb;30(1):61-74.
33. Enjalbert F, Lebreton P, Salat O, Schelcher F. Effects of pre- or postpartum selenium supplementation on selenium status in beef cows and their calves. J Anim Sci. 1999 Jan;77(1):223-9.
34. Manesse M, Delverdier M, Abella-Bourges N, Sautet J, Cabanié P, Schelcher F. An immunohistochemical study of bovine palatine and pharyngeal tonsils at 21, 60 and 300 days of age. Anat Histol Embryol. 1998 Jun;27(3):179-85.
35. Picard-Hagen N, Gayrard V, Andreoletti O, Galea J, Grandjean C, Mandon-Maurice F, Cabanié P, Schelcher F, Toutain PL. Melatonin and prolactin secretion profile in naturally occurring scrapie in ewe. J Pineal Res. 1998 Mar;24(2):117-22.
36. Delverdier M, Abella-Bourges N, Schelcher F, Raymond I, Espinasse J, Cabanie P. Use of monoclonal antibodies for immunohistochemical study of bovine spleen on frozen sections. Anat Histol Embryol. 1996 Dec;25(4):243-7.
37. Clouscard C, Beaudry P, Elsen JM, Milan D, Dussaucy M, Bounneau C, Schelcher F, Chatelain J, Launay JM, Laplanche JL. Different allelic effects of the codons 136 and 171 of the prion protein gene in sheep with natural scrapie. J Gen Virol. 1995 Aug;76 ( Pt 8):2097-101.
38. Abella N, Schelcher F, Delverdier M, Concordet D, Valarcher JF, Espinasse J, Cabanie P. Flow cytometric analysis of bovine CD4 and CD8 lymphocytes: influence of blood sampling and processing methods. Res Vet Sci. 1994 Sep;57(2):163-71.
39. Espinasse J, Thouvenot JP, Dalle S, Garcia J, Schelcher F, Salat O, Valarcher JF, Daval S. Comparative study of the action of flunixin meglumine and tolfenamic acid on prostaglandin E2 synthesis in bovine inflammatory exudate. J Vet Pharmacol Ther. 1994 Aug;17(4):271-4.
40. Delverdier M, Abella N, Schelcher F, Pradeau P, Espinasse J, Cabanie P. Use of monoclonal antibodies for immunohistochemical study of bovine lymph nodes on frozen sections. Anat Histol Embryol. 1993 Dec;22(4):368-75.
41. Espinasse J, Peel JE, Voirol MJ, Schelcher F, Valarcher JF. Absence of circulating TNF alpha in experimental bovine pneumonic pasteurellosis. Vet Rec. 1993 Mar 20;132(12):303-4.
42. Schelcher F, Valarcher JF, Espinasse J.Abnormal ruminal digestion in cattle with dominantly non-digestive disorders. Dtsch Tierarztl Wochenschr. 1992 May;99(5):175-82.
43. Delverdier M, Pradeau P, Abella N, Schelcher F, Espinasse J, Cabanié P. Immunohistochemistry of bovine lymphoid tissue : neutralization of the non-specific reactivities of serum anti-immunoglobulins by bovine serum Ann Rech Vet. 1992;23(4):371-9.
44. Schelcher F, Delverdier M, Bezille P, Cabanie P, Espinasse J.Observation on bovine congenital erythrocytic protoporphyria in the blonde d'Aquitaine breed. Vet Rec. 1991 Nov 2;129(18):403-7.
45. Espinasse J, Navetat H, Contrepois M, Baroux D, Schelcher F. A new diarrhoeic syndrome with ataxia in young Charolais calves: clinical and microbiological studies. Vet Rec. 1991 May 4;128(18):422-5.